I wanted to talk about the Mantoux test, which is spelled "ma n tou X," kind of an interesting spelling after a French doctor who popularized it. Another way you might hear this referred to is as a PPD or a TST. PPD stands for purified protein derivative and gives us a clue as to what we're using in this test, which is TB protein OPA (in parentheses). The location of the test is also going to be kind of a clue here with TST. This is a tuberculous skin test, which tells you where we're going to put all that protein - in the skin. You may have seen this referred to as the "bubble test." A lot of people say, "Oh yeah, my doctor injected some liquid in my forearm and it kind of bubbled up." This is how people usually think about this test - they remember it because it's a very obvious visual. I wanted to give you an example or a diagram of what's actually happening when you get this test done. Let's imagine this is your skin layer, also referred to as the dermis. Below the dermis is the subcutaneous layer, and usually, one of the most common things in that layer is fat. The idea here is that you're basically putting a little needle in there, which is what you're seeing in that picture on the right. That needle is full of TB protein, so the purified protein derivative is in that needle. It's actually going to be injected into the skin. You've got all these little TB proteins in there, and the volume you're putting in is a small volume - about 1/10 of a milliliter, so 0.1 milliliters. You're putting it intradermally, which means it's going into that dermis layer. It's...
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